I'm thinking of John Baine aka TotalBiscuit.

Ten years ago he was the only person i watched on Youtube. He did gaming related content, originaly about WOW and Starcraft 2, later branching out into Indi and AAA games. While he could be controversial as a person he had deep knowledge of the industry and made videos that where 100% made with gamers on mind. The man was a fucking ledgend and there is nobody who has been able to take up his work with the same integritity and knowledge he had.

He was diagnosed with colon cancer in 2014 and died 2018. In his last videos you can hear him slowly withering away.

Here is is talking about living with cancer.

Here is him playing the 2016 Doom release and getting more and more happy / exited the longer he plays it.