The best box sets are ones that support the smaller dev teams, particularly the ones that specifically give a percentage to that team.

The ones that have an extra guide, maybe a figure or item, something special.

Otherwise, I would rather have the digital files only. I really have no need for more crap around the house.

Edmund McMillen and Tyler Glaiel (Mewgencis, Issaac) and going all in. You can buy a subscription to physical Mewgenics boxes delivered to your door.