That's still a little vague. What are you actually trying to accomplish? What material, what size and orientation (perpendicular or angled) of hole, and what is the hole for?
I'm looking for an answer like "I'm pre-drilling before toe-screwing 3/4" oak for the frame of a cabinet" or "I'm drilling out plug welds in 16 gauge sheet steel"
For all we know, you're having an X/Y problem and the best advice might be to use a drill press or even some other tool entirely.