Really depends on what you mean by passkey, since it's actually a fairly vague term for a bundle of technologies.

I don't really care for password manager passkeys; just use a password, all it really does is save you from needing to enter a username in a login flow.

But I'm a big fan of hardware 2fa using non-resident keys ("passkey" lite); I'll use a regular login flow with a password manager, then the 2FA step with a hardware token. Basically bulletproof (ditto if you secure your PW manager with hw 2fa) and painless.