Yes.
I'd just gone to university, my partner didn't and stayed at home. They got very jealous of my university friends and flatmates, being unreasonably hateful towards people I met who were same gender as them... But was OK when I went back home to visit them.
if they came down to visit me, always wanted me to withdraw socially with them, rather than get to know the people and place.
After a few months of that, middle of the spring term I started chatting to someone at a party who was going through a divorce after marrying young. We kept chatting, then about our relationship experiences, and kept drinking.
I ended up heading back with them once things died down because it was closer, but ended up doing an awful lot of not sleeping.
I told my partner a few days later, and our relationship was ended within a week of that.
I felt a bit crappy and some guilt about it.
Feel more guilt about times I've broken up with people for feeling it's not been making them, or me, better/happier/saner, though - and perhaps the most guilt from breaking up with a partner in non-monogamy who didn't want children to get into a monogamous relationship where kids were on the table.