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We don't know. The vast majority of our data on human health is collected at one G. We have a few decades of data from ISS missions at zero G, and have observed loss of muscle and bone density as two major concerns.

We have a few weeks of data from the Apollo missions at one sixth G, but this insufficient to draw any long-term conclusions.

A rotating space station would be very useful to study the longterm health effects of reduced (but not zero) gravity, as the speed of rotation could be adjusted to simulate lunar or martian gravity.

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