I think the interface will be difficult to print. If the underside is smooth, the non sticking material might not stay in place. If the underside is rough ... well then you have a joint with at least one rough spot in it's rotation. Thats just from thinking about my experience with using pla with petg supports (and vice versa) so it may be better than I expect. Depending on the usecase, I think it might work.

But I think it's easier to print a joint in place from a single material and then "snap" it so it moves. Or design something where you print the parts seperately and then assemble.