I use uBlock Origin + uMatrix at the same time. The default blocked stuff from both works for me fine. uMatrix has great flexibility to allow certain stuff. And uBlock has ability to block additional stuff with the element picker, either temporary or permanent. Both tools have additional settings that the other might not cover. So what I usually do:
- let uBlock block ads and some other stuff
- block some stuff manually with uBlock
- let uMatrix block additional stuff but allow me to finetune easily
- allow certain domains or categories in uMatrix one by one for certain sites when I need to