I use a 128GB Framework Desktop myself
then I personally use AnubisLemonade
I gave this a try today to dip my toes into uncensored models (along with a few others like llmfan46/Qwen3.6-35B-A3B-uncensored-heretic-GGUF). It gave some really amusing results. I was definitely not expecting the first thing to come back from "Hello, who are you?" to be "I'm the person who's going to teach you how to cook!" :p
The results I'm getting are a bit slow though. Have you found a way to speed it up on the Framework Desktop?