Political divisions tend to use rivers as borders because they’re naturally difficult to cross, but mountain ranges/watershed boundaries would make much more sense for self-sufficiency among the divisions without excessive squabbling. Although BC/Alberta did a good job in that regard!
So yes, it’s mostly Northern California that could join the Cascadia party. Hence my qualifier of “intact”. Unfortunately, NorCal is predominantly on the red team politically.
It wouldn’t be as devastating (or possible) to cut off the Pend Oreille or Spokane rivers from adding to the Columbia.