I had an on-again-off-again thing with an AFAB person who identified as non-binary for the latter part of that time. Still had a vagina, still enjoyed PIV, still had a body I found attractive, so whatever. Only real difficulty was cutting gendered language out of dirty talk, especially with them being a sub.

Admittedly, I'm kind of a gender-abolitionist anyway. Biological sex I get, I like putting my penis in a vagina. Body-type aesthetic preferences I get, but those are pretty individual in the first place: some people like tits, some like ass, some like skinny, some like thick, some like short, some like tall; there are plenty of women I don't find attractive but others do, and vice versa. But outside that, gender just seems socially regressive. So long as I am sexually attracted to you and you like having sex roughly the same way I do, the rest is just personality.

I'm sincerely not sure how social gender would affect my relationship.