Ok, but the harness is designed to be worn upright, so the hip belt - which usually carries the load most effectively - cannot work properly because the backpack is exerts shear stresses on your spine, I fear. It obviously depends on how much leaned forward one rides, but itβs not the same as standing/walking.
In the end, you know your body better than anyone, just hope you consider well how you set up your bike :) take care and I wish you many good rides!