I guess I just don't understand your question. Explain in more detail.
- Who is the threat actor? (State, APT, Hackivist, etc)
- What is their goal (what do they want)? (Money, data, persistent access, blackmail)
- What tools do they have?
Really think about the Ws (who, what, where, when, how).
If you want to protect against an "advanced" threat actor, you can not do that without multiple layers of isolation, including but not limited to virtualization, MAC (SELinux), namespaces, seccomp.
All protections are meaningless without a clear understanding of what assets you are protecting, the threat you face, and they want from you.