For those unfamiliar the Dune series, the Butlerian Jihad was a crusade against “thinking machines”. Ultimately computers, and intelligent or thinking machines, even down to calculators are destroyed and banned. Humans who are trained in complex mental maths become known as Mentats, a sort of human computer. Just, uhh, leave all that shit on Bene Tleilax, with their Axalotl Tanks out of it.

Edit: had wrong planet name. IX -> Bene Tleilax