I literally posted the same suggestion in this community three days ago as a joke!
Double post, but uh, also kind of worth noting that roughly the border between UAE and Oman...
... is a mountain range.
So you'd have to go through the passes, which of course already have highways and towns.
... and basically everything south of Abu Dhabi is a nature preserve.
Also, not sure how out of date this is, but:
Presumably, you would not want to nuke an already existing oil pipeline.
... which my NukeMap 'path'... does, basically.