I've been on it for a bit over a year now and honestly, it's just the new normal. Can't really say I miss anything, and things like the separate profiles are pretty neat.
Although, I have bricked myself once by enabling developer settings and accidentally changing my language to a dev-only language that made the os crash on boot. But the Graphene Devs fixed it and unbricked my phone within a week after I posted the problem to the forum.