I tend to play on easy mode now.
If I am being honest, I 'think' there's a part of Rimworld's gameplay that I like and another section I don't like as much, so now I find myself setting up mods and special difficulty modifiers to work towards whatever this other gameplay style is.
Also it doesn't help that many mods (though quite cool) are semi-unbalanced and raids are based on your colony's financial status - Which leads to the default difficulty settings being way overdone.