Yeah it's awful to figure out what to do when the normal pain killers don't work. Woke up during a surgery cause it lasted just long enough for them to get started.

but yeah if you have the enzymic issue I have increased dosages don't help and doctors will question you over and over again as if we have more information about it. I don't get how it works either but it seems to be genetic, most of my immediate family has it too.