(TBoI:Re = the Binding of Isaac Rebirth)

For the curious, the combo is Chaos (the smile) + Holy Light (the eyes).

A screenshot of The Binding of Isaac Rebirth, showing the protagonist, Samson in this case, with a smug face and shining blue eyes.
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[–] 3 points 9 months ago

I believe chaos creates that smile... I think it's a reference to the old troll face memes.

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