Can run decent size models with one of these: https://store.minisforum.com/products/minisforum-ms-s1-max-mini-pc
For $1k more you can have the same thing from nvidia in their dgx spark. You can use high speed fabric to connect two of ‘em and run 405b parameter models, or so they claim.
Point being that’s some pretty big models in the 3-4k range, and massive models for less than 10k. The nvidia one supports comfyui so I assume it supports cuda.
It ain’t cheap and AI has soooo many negatives, but… it does have some positives and local LLMs mitigate some of the minuses, so I hope this helps!