I think that #2 is a bit subject to the situation. Like somebody's elderly grandparent who happens to have incontinence issues and dementia should not be mocked because of those.
But the guy who's leader of a powerful nation, takes constant shots at everyone else, and whose party actively CAMPAIGNED on his opponent being old and infirm... yeah that seems like fair game.
Shitting your pants in the nursing home versus the white house oval office are two very different scenarios