Well, I use an XP Pen display tablet, so effectively a second monitor. I've used both Krita on Ubuntu using X11 (in 2024 and before) and since the start of 2025 been using Bazzite which uses Wayland.
Can't say I've run into any display specific issues. Pen tracking gave me some trouble, but it was some setting in KDE and Open Tablet Driver I had to play with to fix that.