I do audio mixing and having another scroll wheel is very nice up to a certain point. Per track volume, master volume, send volume, panning, scrubbing, jogging and fine jogging, track height, nudge....

I'd have to go look but I have something like 12 rotational devices programmed (it's a macro pad with a bunch of layers and 3 wheels). Some of them I don't use very often. Some get used every time I sit down. Because of them and way too many hours planning and setting my macros I rarely touch my mouse or keyboard anymore. It's either done at the mixer or on the macropad.

ETA: I just looked again. The way it works would be incredibly cool for jogging the play head a single tick at a time. I already have a solution for that, but if I didn't I would totally give this a try.