Depends on the thing. Biological imperatives are kinda baked in genetically, for example. And how much "will to power" you have (in a Nietzschean kinda way) about different topics will determine how many fucks to give about any particular thing. There is probably some brain science that can point to particular regions as drivers of this process, which then becomes a mix of genetic predisposition, and also environment/experiences that shape brain development.

But take all of this with a giant grain of salt. These kinds of questions will have shades of an answer from different perspectives: philosophical, scientific, religious, etc. None of them are 100% correct because we still don't even understand consciousness