There isn't really a scientific measure of how confusing something is linguistically that I am aware of. As you and other people have pointed out, there are plenty of languages that don't differentiate orthographically between numbers and letters. It's like asking whether people will confuse read and read. Yes, they probably will in some cases, but on some level speakers understand that these words are written identically and that you require context to figure it out. So they would know the difference much more often than not
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