There's another whole category that also doesn't care about what the game is running on the kernel: seperate device cheats. They act as a man in the middle for the input and output signals, and can auto shoot when you'll hit or adjust your aim if you're close but not quite there. Or just play for you entirely if it's that good at processing the output.

And blocking that isn't likely possible without killing streaming for the game or convincing all users to get input devices with encrypted connections or they can't play your game.

I'd respond to the original comment that anyone who doesn't have server side cheat detection isn't serious about stopping cheaters. In any case, I just removed that game from my wishlist. Not that I needed another survival builder game anyways, though they do tend to catch my eye.