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[–] 139 points 1 year ago* (last edited 1 year ago) (22 children)

In the long run, using mice to test human medicines will result in selection pressure for humans whose physiology more and more closely resembles mice.

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  • [–] 58 points 1 year ago (10 children)

    they use a lot of other things… including living human cancer cells in a petri dish

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  • [–] 9 points 1 year ago (3 children)

    I believe the vast majority of cultivated human cells are cancerous cells anyway.

    https://en.wikipedia.org/wiki/Henrietta_Lacks

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  • [–] 6 points 1 year ago (2 children)

    when researching cancer drugs, yeah

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  • [–] 2 points 1 year ago* (1 child)

    Actually it's used in everything, it's available, it's well studied, it's cheap, and most importantly it grows fast in a lab, so it's easy to work with....

    I wish I was joking, but lots of in vitro human research is done on the poor women's cancer cells when the research has nothing to do with cancer, it's quite the confounder

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  • [–] 8 points 1 year ago* (last edited 1 year ago) (5 children)
  • [–] 2 points 1 year ago (1 child)

    That's not how evolution works though

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  • [–] 1 point 1 year ago

    Assuming that

    • human phenotypic traits that correlate more closely with mouse traits have more-predictable outcomes with mouse-tested medicine, and

    • more-predictable medical outcomes correlate with higher survival and reproductive rates,

    can’t you plug that straight into the Price equation?

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  • [+] -19 points 1 year ago* (last edited 1 year ago) (3 children)

    Mice, notorious for having evolved to suit unclean conditions and being able to survive as carriers of disease and parasites will definitely have a different set of evolved resistances and immunities to us. It's pretty ludacris science believes them to be a good point of comparison.

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  • [–] 1 point 1 year ago

    It's just an early testing phase, more of an "ok, this drug kind of did what we want in mice, and the mice didn't explode. It's time to move to the next stage of testing on something more human analogue, like a pig."

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