The easiest way to mod Skyrim on Linux is to install a modlist with a tool called Jackify. See my other comment for a guide. Downloading modlists will cost one month's subscription fee to Nexus Mods, but it saves a lot of time and effort.
Mods typically have very limited scope: they often do only one small thing. And they have dependencies, and the dependencies might have dependencies. To install a mod, you need to install all the dependencies, and then you need to set them up correctly. You'll end up reading a novel's worth of install instructions and spending hours upon hours of your time for all of that.
Using Jackify configures the Wine/Proton prefix so that the modlist, Skyrim and ModOrganizer2 works more or less correctly. Modlists can contain hundreds of mods, and all you need to do is pay the subscription fee and Jackify takes care of the rest.