I've been trying different flavors on my machines with Nvidia cards. It usually just works well enough for me. Did Garuda for a microsecond, mint for a moment, Ubuntu for a few, and am now trying Debian and Endeavour. I've honestly had more issues coming from arch peculiarities than from nvidia. Just give it a go if you have the drive space. It seems like there's more of a question of how well your chosen flavor meshes with your chosen hardware than one of 'can I even get this working?'