I guess I may have missed two other benefits:
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Only one vehicle to store - don’t NEED to store a trailer
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If you need to haul your own trash to the dump, having the cabin separate from the bed is a big plus
But, as you said, a trailer if you have room for it is certainly a good option.
To my knowledge most wagons are unibodies and you really need body on frame to achieve high towing capacity.
If you can afford and have space for two, maybe an F250 (please tell me you don’t need an F650 for the cars you’re hauling lol) and a daily might be worth it