We get 100s of automated applications per day for a position we recently opened. 99% are automated and no where near meeting the requirements. We try to give everyone a review and a reply but it is a massive task, unfortunately. We do not have dedicated personel to handle these matters so it costs engineering time. The current situation for online software dev job application sucks for everyone.
I guess what I am trying to say is: If you don't get a reply to an application it is likely because you are drowning in noise and someone at the other end is struggling to keep up.