I’d recommend finishing a playthrough unmodded first just to get the vanilla experience, but definitely replay it modded. Alternate Start, A Quality World Map, SkyUI, Unofficial Skyrim Special Edition Patch, and many graphics and texture mods. Plus mods that add new quests, new areas, new weapons and armour, perks, followers, anything you can think of. Plus tons of goofy mods. It’s a modder’s dream.