Raul Julia - Street Fighter.

The land before time - Duckie's VA :(

• Heath Ledger: The Imaginarium of Doctor Parnassus
• Paul Newman: Cars
• John Wayne: The Shootist
• Clark Gable and Marilyn Monroe: The Misfits

According to a recent Red Letter Media video, Sean Connery's last role was voicing the title character in "Sir Billi," Scotland's first feature-length computer animated film.

"A retired veterinarian living in a remote Scottish village encounters a goat who thinks he's a dog, an Admiral who's afraid of the water, and a beaver who was raised by rabbits."

I believe that the 1986 Transformers: The Movie was Orson Welles's final role! He sounds pretty good, but I think there was some audio processing done to touch up any roughness

I havent seen it, but Ma Rainey's Black Bottom was Chadwick Boseman's final film.

Actually, his last six films: Black Panther, Avengers: Infinity War and Endgame, 21 Bridges, and Da 5 Bloods were all filmed after his diagnosis and during his treatment.

He went out like an absolute giant.

e: Damn, now I have to add Giant, James Dean's final film.

An American tail: Fifel goes west, last John Stewart voice role.

Kubrick

Eyes Wide Shut

He was trying to warn us and here we are

Salome's Last Dance

https://www.themoviedb.org/movie/70842-salome-s-last-dance

Imogen Millais-Scott's first and last film. I read she had diabetes and was very weak and nearly blind during filming, not sure about info about her.

https://www.themoviedb.org/person/559811-imogen-millais-scott

I may have missed something obvious here, but why "final"?

Final Destination: Bloodlines for Tony Todd.

I wasn't his biggest fan and I've never seen Candyman, but his farewell in Bloodlines honestly really got to me.

You'll have to include Saratoga. Jean Harlow was dying/died of kidney failure during filming. See if you can spot the doubles they used to finish the film.

Anything staring Bruce willis after ~2010.