Yeah. With Wabbajack or natively. Theoretically.

I think some issues are:

• A lot of Nexus modders have weird possessive licenses, eg "you have to manually download my mod, you can't use my mod with X mod," and so on.

• Some mods need manual fixes (though Wabbajack should be able to do most of this).

• There are a lot of external tools as part of the setup.

• Lexy seems to be an "oldschool" modder. They seem wholy untinterested in trying to automate it. It's ultimately their time to spend on the pack.

Last I checked, some folks have tried to automate the installation, but I have no idea what progress has been made, and it seems Lexy's page is still full manual.

...But if you're manual mod picking anyway, and interested in learning modding in depth, it's quite a guide to follow. It’s been built and refined over like a decade.