At the beginning it's just ambiguous, the jokes seem to try to tackle racism and discrimination while being a little discriminatory here and there, but overall not so bad. But the more the show progresses, the more it shifts into a lot of crap, spitting shit that you can tell directly comes from "anti-woke" bullshit and other far-right ideology.

Even the character of the rapist sect leader is sort of shown in a "more stupid than evil, and actually funny" view, which I still cannot understand

Well for example there is a whole episode where "woke" people are mocked by showing them as ignorant and pathetic, to the point where it ends with one them offending themselves and exploding out of the frustration.

That's just one thing from the top of my head. You could also talk about Tidus that ends up being shown as a pathetic useless crap, defined by three things that what the show deems more essential than the rest: he's gay, fat and black.

One of the recurring (fatphobic) jokes is that he eats mayonnaise jars with a spoon, because everyone knows that that's why obese people are obese, they're just lazy stupid jokes, right? /s

And to quickly surf above random other examples, the whole Reverend thing is showing that it was mostly the victims' fault for being too stupid while joking about rape, the character of Lillian is used to spit out a lot of racist shit because "she's a funny old woman" but she's still shown as a nice person somehow ; there's an episode showing one of the victims trying to become a kidnapper too (wtf?) but ending up being taken seriously by no one because everyone automatically assumes that as a stupid woman she's basically nothing more than a housewife.

Each episode gets worse than the next and conveys increasingly immoral viewpoints, so I'd frankly question your wife's morals if she really liked the show.