I think you mean LiveUSB, but it depends on the game. If it's a large game, it's going to install and run from USB, so it's not going to perform well. Small games that fit in memory will be fine.
If you want to specifically take steps to make this work better, get an external SSD and turn the Live Image that way. It's still not going to perform well with large games, but multitudes better than from USB.
Unless you have a specific game to try, you'd get better info from ProtonDB, or comments online to find out what the general feeling about performance is going to be.
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