Oh boy yes, but mostly early internet memes, when 4chan was the bleeding edge of internet "culture". Shit like advice animals were spammed to hell and back until they got enough natural momentum.

Probably some shitty memes were made for the express purpose of being a meme, but the good ones take from something else as you said. It's like when someone tries to get everyone to call them Dominator but their name is Jeff.

Batman Beyond

The green guy is Derek Powers aka Blight. He finnaly lives in a sub since his skin starts to fall off.

Batman: "You killed my father." Blight:"Do you have the slightest idea how little that narrows it down?"

Source: I really liked this show when I was a kid.