Integration with macOS and features like synchronization with iOS/iPhone or generating new iCloud mail addresses.
I always use other browsers in parallel. Sadly they typically fail to adhere to macOS UI conventions or don’t integrate as well across devices.
I use Waterfox (Firefox fork) as a secondary browser because of the more powerful extensions. Other than that usability and OS integration is worse.
Camino used to a be a good Mozilla/gecko browser back in day. Sadly it was abandoned a long time ago.