I just deal with the one time effort of unblocking a new site. However this had my filter list grow to the point where it can't be synced through the cloud anymore.

uBlock can do the same things as noscript afaik, so you don't even need noscript anymore (and yet Tor forces it...), but yeah other than saving your global and site based decisions, I'm not sure you can avoid having to toggle domains for every brand new site you visit...

For really annoying pages i have to allow two or three other domains, and theres an element of guesswork unvolved in figuring out which scripts are relevant to the page loading or not. Thats only on the first time you visit that site. But on the sites where you want it most, id vastly prefer refreshing 2 or max 3 times allowing gradually additional scripts each time, than just letting them call whatever the fuck they want from whatever domain. Every time that happens i end up allowing 2 or 3 urls, and sometimes there's about 40 that i dont recognize or actively don't want.