until now I had organized my papers into a large pile, and finding any paper was a horizontal nightmare. Now they are all hole punched and in a binder... because i staple in the top left of the paper, i hole punch on the right side; so that i can quickly browse the papers in the binder (staple out).

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[–] [S] 4 points 1 day ago (2 children)

https://doi.org/10.1038/s41380-024-02431-w

Am I reading this correctly — the hypothesis is that bipolar mania is downstream of how bipolar people metabolize sugars? Like when you give kids too much sugar and they’re hyperactive (allegedly)? That’s bananas!

kinda - after a long enough time of sugar overload the brain insulin ratio gets skewed and there is a brain energy crisis that may be the underlying etiology of various brain issues including bipolar (and maybe hyperactivity).

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  • [–] 2 points 20 hours ago (1 child)

    I know I should read the paper because you linked it... But I'm curious about that as a hypothesis because I would have presumed that people with poorly controlled diabetes with a higher HbA1c would the have higher rates of brain issues ? Aside from the vascular cognitive impairment it's nothing I've noticed anecdotally

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  • [–] [S] 2 points 20 hours ago* (last edited 18 hours ago)

    It's a hypothesis paper framing the guidelines for future research.

    Yes, poorly controlled t2d is at greater risk for NDDs as far as I'm aware.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC7358107/ - Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data

    I have not read this paper, but it has a graph that is illustrative

    comorbidity graph

    odds ratios tree

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