I think as an immigrant, I might actually more qualified than Americans to answer that. And broadly speaking, yes. The accents will vary; the conversation isn't rehearsed so there are a lot more uhms, ahs, and interrupting one another; witty banter is less prevalent; stuff like that that is the usual differences between a script and real life. But the cultural differences? They're there. Most US media is incredibly grounded in their reality. I caught myself befuddled in many situations because it felt surreal, like I was in a TV show. I couldn't believe what I watched on the TV was real and not just something contrived to drive the plot where the writer wanted. But it was real.