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[–] 16 points 1 week ago* (3 children)

There are over a hunderd different types of cannabinoids.

They all have different effects on the unique brain chemisty of an individual but also influence the effects of eachother. (Entourage effect)

There are an uncountable amount of combinations here with an uncountable amount of specific effects.

It has to be said that all drugs carry real risks and cannabis is not harmless.

But with the info above i have always believed in its potential to one day synthesize fully personalized medicine. Other then many other drugs endocannabinoids are also created naturally in the mamal brain and are very important for mood regulation and cognitive function.

An interesting fact is while people would shudder by the idea of giving these substances to infants, breastmilk is actually a huge source of natural cannabinoids.

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  • [–] 8 points 1 week ago (2 children)

    This kind of touches on something that has always rubbed me the wrong way about medical marijuana

    And don't get me wrong, if it helps you, or if you just enjoy it I'm all for your right to use it however you want

    But you've got a headache or heart condition or whatever, your doctor wouldn't just say "yeah, you should go find some willow trees and chew on the bark of a couple different ones until you find one that works for you"

    No, they'd tell you to go take X milligrams of aspirin, Y times a day, with or without food.

    Because we know what chemicals in the willow bark are actually helping with your problem, we've isolated it (and improved upon it) and worked out specific dosage guidelines based on things like age and weight to treat certain issues.

    But with medical marijuana, it's more of a "go ahead and figure out what works for you" situation. There's a lot of different strains of different potencies with different amounts of different active ingredients.

    And sure, your doctor might be able to make some recommendations that you want a strain that's high in one cannabinoid but low in another to deal with your issue, and the people at the dispensary can help you through that as well.

    But really, if we're going to treat it like the medicine it is, we should probably be dosing measured amounts of specific cannabinoids in purified forms in pills, tinctures, inhalers, vapes, etc.

    And you probably shouldn't be smoking it. You can quibble over whether or not marijuana smoke is worse, less bad, or about the same as tobacco smoke health-wise, but I think we can all agree that inhaling smoke of any kind is probably bad for your lungs and you're better off not doing it. If nicotine could be used to treat some disease, I'm pretty sure your doctor wouldn't say to go smoke X cigarettes a day, they'd tell you to get some gum or a patch, or at least vape instead.

    And with the state of marijuana laws, healthcare, and general affordability, it can be hard to even do the research needed to make that happen, let alone set up the kinds of infrastructure needed to make those more personalized cannabinoid medications, and of course all of the ways pharmaceutical companies would overcharge us for those meds, so again, I'm glad that what we have now is at least available to those who need it

    But that doesn't mean we shouldn't be looking at how to do it better and treat these chemicals more like other medications are.

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  • [–] 4 points 1 week ago* (last edited 1 week ago)

    I agree fully with wat your saying here.

    Strains also are limited in their range cannabinoids and smoking of any kind is always bad.

    The potential i am seeing in cannabinoids rather then “medicinal marijuana” is that we can isolate and produce new drugs with exactly the amount and combinations needed.

    So exactly like the tinctured and pills you mention that are lacking now.

    Rather then trial and error we might be able to one day meassure and profile the natural endocannabinoids in individual people, then build a pill that gives them exactly what they need.

    Its probabmy more sci-fi then science at this point but it seems reachable. There are some studies that have shown that certain disorders (adhd, some flavors of autism) do produce less natural endocannabonoids on their own. Currently those people often do end up smoking to self medicate. Some proper science on the topic could really help them.

    To add on my previous mentioned little fact about breastmilk cause it is analog to this. There is a suggestion that there is a chemical reaction going n during breastfeeding with milk that flows backwards and tells the mother body how to finetune the milk for the babys current needs.

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