Add vaft script to ublock. It works for me https://github.com/ryanbr/TwitchAdSolutions#scripts

For unencrypted streams, Alternate player extension works (and I prefer it to twitch's player) https://addons.mozilla.org/en-US/firefox/addon/twitch_5/

For android, patch Twitch using Morphe https://morphe.software/

Ah, another reason to not use Twitch.

https://f-droid.org/packages/com.github.andreyasadchy.xtra

https://grayjay.app/desktop/

(willing to switch grayjay out for a less fascist adjacent option if anyone is aware of one for desktop)