I'm not a perpetual DM but I'm the default among my friends. I've played D&D editions since 2e in school, up to 5e. I've also played some PF, WoD (mage and an ill-fated werewolf campaign) Fate, Gurps, Paranoia and a few others I'll trim from this list for brevity.
I got fed up with D&D over decades failng to make martial characters feel impactful and interesting, magic characters having overly broad ranges of abilities that obviate martial characters, and with how long it takes for character ability to overpower randomness in the d20 system in general. I ended up writing a far future science fantasy setting and associated fate-like ruleset that I'm running now in a playtest to moderate success. I wrote out a custom VTT character sheet with automated dice rolls and math to ease my players into things, and I got a lot of engagement from them that's helping me polish.
I've always preferred homebrewing for the surprise it brings but I bit off... a lot with this approach. Chewing it is proving difficult. Being able to say yes to my players ideas more often and fleshing out noncombat play more feels worth it though and I'm having a lot of fun.