A new case report published in Frontiers in Neuroscience describes an extraordinary but highly preliminary observation: an 80-year-old woman with advanced Alzheimer's disease showed temporary multidomain improvement after receiving a high dose of psilocybin-containing mushrooms.

Following administration of 5g of mushrooms, she entered a prolonged deep sleep-like state. After waking, she reportedly regained the ability to speak in full sentences, recognised family members, dressed independently, and recovered urinary continence after five years.

A later 3g dose appeared to extend some of these improvements.