The nuclear deal with Iran that Obama led fell apart when Trump reneged, even though Europe, China, and Russia were all part of the deal and still in. In this case, Israel will keep attacking and has kept attacking even when the US has signed a deal, and since this has been the main issue, there cannot possibly be any deal that works under these conditions. The US is the largest supporter of Israel, so they'd have to pull that support and sanction before Israel maybe stops, but even with dropped support and sanctions, Israel is a death cult and may turn to using nukes to keep going.