If self driving cars actually take off in mass, I personally think we may see more and more of these occurring. Not how they are now, but in the way busses currently work, no driver required.

If it doesn't require any sort of work to drive, people would just set up their car with their entertainment and 1 hr+ drives become a LOT less tedious. And then these cities that don't really have a lot going for them other than being sorta close to a bigger city will slowly depopulate. If you can get to a better city with more services why not? Anyways that my theory.

I also think as the older crowd make room for the youngins, we will begin to see much less population (or at least a huge slowdown in human beings made). The baby boom bulge is getting into retirement and theres going to be a LOT of houses popping up. More inventory means prices go down. Climate change may change that equation as things get drier/hotter in most of the US so im less sure about that. But less people being made means less housing needs to strain generally.