Gonna preface this with: I completely understand your difficulty, I have several autistic people in my life and I know that it's important to make reasonable accommodations to help make life easier. However conversely, a reasonable accommodation must not invalidate the initial reason for the accommodation in the first place. If the point is humour, it's a hard sell to force someone to, from their point of view, remove the humour from the humour. You wouldn't knock down a monument to install a lift to get to the top, sure the people with mobility issues can get to the top now, but the monument is no longer there to see.
Given that, an audience freely laughing at a joke is very different from a comedian demanding you laugh immediately after each joke, which would be a more direct comparison. The latter drains all humour from the situation, the former arguably elevates it.
Personally, if the point of a comment is to post something that I think is amusing, there's no point in doing it if I have to compromise what constitutes the humour to me, otherwise I'd just be posting something unfunny, defeating the object of it entirely.
That and it's the internet, we all have a better time if we go with the working assumption that the vast, vast majority of comments are entirely unserious.