Sure, but the user appears to be a Piefed.social user, so I don't see the relevance?

The comment is vague enough that it could be about any number of issues. I don't understand the anime reference in the meme, so it may be something along those lines, or it may be that they found the joke 'normie' and unfunny on account of it being a reaction. I prefer to get a clarification before upvoting or downvoting.