"inflammation is now understood to be a key mediator of OA that contributes to cartilage loss and progressive degeneration of affected joints... OA is no longer considered a noninflammatory arthritis or a 'wear and tear' disease"

I heretofore thought age-related cartilage loss was the cause of osteoarthritis and inflammation. Turns out it's the other way around: the inflammation degrades cartilage. Okay, no more slogging through joint pains for me, regardless of how small.

Edit: added a phrase for clarity

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[–] [S] 2 points 6 months ago

Huh, a TIL within a TIL! :D I came across this systematic review (https://pmc.ncbi.nlm.nih.gov/articles/PMC4622344/). Looks like for cortisone <6mg is the sweet spot.

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